Magic Mushrooms in Massachusetts

The Boston Psychedelic Research Group at McLean Hospital (Harvard Medical School affiliate) is one of the most active academic psilocybin research programs on the East Coast. Led by Dr. Eli Kaplan (MD, PhD), the group runs FDA-registered clinical trials of psilocybin for treatment-resistant depression, OCD, and alcohol use disorder, with a particular focus on the neurobiological mechanisms underlying therapeutic response. McLean's research infrastructure — including neuroimaging facilities, an established inpatient psychiatric unit, and long-standing IRB relationships — enables trial designs that community-based research organizations cannot execute. Current enrolling trials include a psilocybin-for-OCD study replicating and extending the Moreno et al. 2006 work, and a mechanistic neuroimaging study examining DMN connectivity changes as predictors of therapeutic outcome. Massachusetts does not have a regulated psilocybin access program as of 2026. Ballot initiatives are in development; advocates expect a 2027 or 2028 vote. In the interim, clinical trial participation is the only legal psilocybin access pathway in the state. Trial participation is free for qualifying participants.

Last verified: 2026-05-21

The overall objective of this study is to assess the feasibility, safety and preliminary efficacy of psilocybin-assisted therapy to alleviate opioid-refractory pain in patients with advanced-cancer. The name of the study intervention used in this research study is: Psilocybin (a tryptamine derivative) Source record lists lead sponsor Yvan Beaussant, MD, MSci and overall status Recruiting.

Last verified: 2026-06-12

This study aims to determine the safety and preliminary efficacy of psilocybin-assisted psychotherapy in improving alcohol-related outcomes among adults with severe alcohol use disorder in a a double-blind, dose-comparison concurrent control, randomized trial. Participants will undergo structured psychotherapy and will be randomized to two psilocybin sessions to receive either a full dose (30mg or 40mg) or low dos... Source record lists lead sponsor Brigham and Women's Hospital and overall status Not Yet Recruiting.

Last verified: 2026-06-12

Boston-area mushroom delivery service operating in decriminalized Massachusetts cities. Listed in prior directory data and retained as an active decriminalized-market listing. Current contact information should be verified before ordering.

Last verified: 2026-06-15

Mushroom delivery and gifting service in decriminalized Cambridge, Somerville, and Medford, Massachusetts. Operates a membership model requiring account creation. Recommended online as a professional sticker-gifting model.

Last verified: 2026-06-15

South Boston boutique wellness shop carrying hemp-derived THC, CBD, legal mushrooms, kratom, kava, blue lotus, and alcohol-free beverages. Founded in 2019 with third-party tested products. The legal mushrooms category may be Amanita-based rather than psilocybin, so verify product type before listing as psilocybin access.

Last verified: 2026-06-15